Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins

Contemporary approaches for modifying the mouse genome

The mouse is a premiere experimental organism that has contributed significantly to our understanding of vertebrate biology. Manipulation of the mouse genome via embryonic stem (ES) cell technology makes it possible to engineer an almost limitless repertoire of mutations to model human disease and assess gene function. In this review we outline recent advances in mouse experimental genetics and...

Law and Economics: Contemporary Approaches

Contemporary Approaches to Concept Development

In the past several years, developmental researchers have begun to transform the vantage points from which we study concepts and their development. This essay begins with a brief and selective critique of two major psychological theories concerning the structure, representation, and development of concepts (the classical view and the prototype view). This is followed by a discussion of fundamen...

Storable palladacycles for selective functionalization of alkyne-containing proteins.

We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

Process Flexibility: A Survey of Contemporary Approaches

Business processes provide a means of coordinating interactions between workers and organisations in a structured way. However the dynamic nature of the modern business environment means these processes are subject to a increasingly wide range of variations and must demonstrate flexible approaches to dealing with these variations if they are to remain viable. The challenge is to provide flexibi...